Bentham eBooks: The Inflammatory Milieu of Tumors: Cytokines and Chemokines that Affect Tumor Growth and Metastasis

Bentham Science Publishers is a major STM journal publisher in the industry. It publishes 116 online and print journals, 150 plus open access journals, and related print/online book series, Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences.

Tumor development and progression are multi-factorial processes, in which genomic alterations and modifications in gene expression in pre-malignant cells are joined by deleterious microenvironmental factors. The tumor microenvironment contains stroma cells and leukocytes, soluble factors and matrix components. The intensive interplay that exists between the host factors and the tumor cells plays a major role in dictating the final outcome of the malignant process.

Inflammatory mediators are pivotal microenvironmental factors present in the tumor milieu. These inflammatory components support cell growth and invasion, induce mutagenesis, increase angiogenicity, and suppress potential anti-tumor immune functions. The inflammatory constituents that prevail in tumors include leukocytes and soluble mediators - cytokines and chemokines.

This e-book describes the roles played by these mediators in malignancy, and explains the basis for their consideration as therapeutic targets in cancer.

The e-book is a timely overview of the roles played by inflammatory soluble mediators in neoplastic diseases. The topics addressed in this volume serve as a handy reference to investigators studying basic aspects of the malignant tumor growth, to clinicians who wish to better understand the processes involved in malignancy, and to pharmacological professionals seeking novel candidates for therapeutic intervention in cancer. 

For the purchase of this eBook and other details, please visit: http://www.benthamscience.com/ebooks/9781608052561/index.htm

Depression! The Most Common Mental Illness

Mind is a complicated organ, and works in mysterious ways. Depression is one the most common mental illness that exists. It is not a feeling of staying sad but it is a constant feeling of being sad and lacking interest in everyday events. Depression leads to emotional and physical issues as well. Its symptoms vary from person to person.

 Most common symptoms are:

·         A constant feeling of sadness, anxiety and emptiness.

·         Individuals feel restless and hopeless.

·         Fatigue sets in and the energy level decreases gradually.

·         Sleeplessness.

Depression can be triggered by environmental, genetic, biochemical or psychological factors. Most specialists say depression is a lifelong illness and cannot be cured. But the patients of depression can be made better by ‘talk therapy’ and ‘antidepressants’. According to the National Institutes of Health, a significant percentage of people with depressive illness never seek medical help. This is unfortunate, because the vast majority, even those with very severe symptoms, can improve with treatment.

Bentham Science Publishers is one of the leading journals in the STM industry. It has journals and eBooks pertaining to topics from science, medicine, technology and the like. Neurobiology of Mood Disorders is a monograph is a collection of selected articles on the subject of mood disorders such as depression and schizophrenia. 

Psoriasis- A Chronic Skin Condition:

Psoriasis is an acute skin condition that causes inflammation and scaling. It is developed by an abnormality of the body’s immune system, as the immune system that fights infections and allergic reactions. Psoriasis is a hereditary condition and most of the patients have a family history of this disease. Certain drugs may also trigger psoriasis.

It causes skin scaling and inflammation and itching. Most of the people have another symptom of having abnormal and thick fingernails known as pitting.

Psoriasis has several types, such as plaque psoriasis, inverse psoriasis, pustular psoriasis, guttate psoriasis. Psoriasis Arthritis is also one of its types, which affect people suffering from psoriasis. It occurs internally before it appears on the skin.

It is physically diagnosed by analyzing skin and nails. Skin biopsy is often recommended by doctors, which confirms the diagnosis and rules out other possible skin disorders.

Unfortunately, psoriasis is a long-term illness and there is no way to prevent it.  However, there are numerous treatments available for this condition depending on the type of psoriasis, affected area of the skin and its extent.

Some of the treatments include: oral medication, topical treatment, daily skin lubrication, petroleum jelly and salicylic acid. In addition to, phototherapy which is a treatment that uses ultraviolet B or A rays. Laser treatment is said to be effective too. Vitamin A, immunosuppressant, antineoplastic agents, and biologic therapies could also be used.

Bentham Science Publishers is a distinctive name in the STM industry. An eBook “Dermatological Treatments”  is available on http://benthamscience.com/ related to skin related conditions.

Mood Disorders: Depression and Bipolar

Mood swings is a common phenomenon which is experienced by everyone once in a life time, but those with a high intensity suffer from mood disorders. Depression, disturbed physical health, and prolonged depressing emotions that affect people mentally are some of the symptoms.

Bipolar disorder and depression are known as manic depression; both are serious medical illness but are curable.  In bipolar disorder patients suffer from extreme depression to the extent that they feel really high and uncontrollable, which as a result makes them behave in a hasty manner.

Depression on the other hand is the most common type of mood disorder. Usually depression is caused by severe emotional setback or it could be a side effect of an illness or its medication. A depressed person feels low, tired and hopeless. Sleeping and eating patterns become abnormal and the patient loses interest in everything around him. Proper counseling and medication can help the patient live a normal healthy life.

Bentham Science Publishers covers a variety of topics in the fields of science, technology, medicine, natural sciences and social sciences. Here is one of its eBook “Neurobiology of Mood Disorders” that incorporates discourse related to mood disorders.

Recurrent Anger Outbursts Linked To Chronic Inflammation

According to a study conducted by Dr. Stephen H Boyle of Duke University Medical Center in Durham, North Carolina, recurrent blow-ups like road rages may be linked to have a biological basis. Display of hostile outbursts characterizes a mental illness known as Intermittent Explosive Disorder which also shows signs of inflammation, according to a blood test analysis by researchers.

CNN health explains Intermittent Explosive Disorder (IED) as a behavioral disorder characterized by extreme expressions of anger. While ‘Inflammation is the body’s effort to prevent the body against external or internal pathogens. When the body faces a danger, it reacts by inflating the particular body part, and begins the healing process.’ [To read more on inflammation:Inflammation: An Innate Immune System]

The people who have diagnosed with the condition suffer from episodes of out of proportion aggression. Whenever anger is triggered, they completely lose control on minor things, hurt people, throw belongings and break property.

Research indicates that elevated level of C-reactive protein and interleukin-6, which indicates inflammation in blood, are said to be linked with impulsive and aggressive behavior in people. There is a cause and effect relationship between inflammation and IED.

Presently, medication and behavioral therapy are used for treating IED, although these methods are less effective. It’s important for the people suffering from this condition to seek treatment, rather than expecting their family and loved ones to live with their hostile and aggressive behavior.  Moreover, inflammation also put people at risk for other medical complications such as heart attack, arthritis and stroke.

Bentham Science Publishers is one of the leading STM publishing companies. It publishes 116 online and print journals, 150 plus open access journals, and related print/online book series. One of the latest journals is “Inflammation & Allergy - Drug Targets”. The journal aims to cater to the discovery, identification, characterization and validation of novel human drug targets for anti-inflammation and allergy drug discovery continues to grow, this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

SCHIZOPHRENIA-AN ACUTE CASE OF MENTAL DISORDER:

Schizophrenia is one of the acute cases of mental disorders. This disorder involves chronic and severe disability in the brain. The exact cause of this illness is still unknown. But through research analysis the researchers concluded that this chemical imbalance is multifactorially inherited. The amalgamation of genes from parents and numerous other factors which contribute to its development are genetic, behavioral and environmental.

According to World Health Organization, Schizophrenia affects about 24 million people worldwide. Consulting a doctor is vital before concluding the symptoms to be schizophrenic, as they may look similar to conditions in other mental disorders.  A psychiatric then contribute in a comprehensive set of mental health assessment to determine the best healing for the patient.

Bentham Science Publishers is a remarkable scholarly journal publisher and has been serving the academia and libraries for the last 25 years. One of Bentham Science Publishers high impact factor journals is ‘CNS & Neurological Disorders - Drug Targets’  .This journal publishes guest edited thematic issues written by leaders in the field covering a range of current topics of CNS & neurological drug targets. This journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

DEVELOPMENT OF KIDNEY THROUGH STEM CELLS:

The researchers have developed a unique procedure of developing a mini kidney via stem cells. This appears to be a breakthrough achievement for the patients suffering from kidney diseases.

Kidneys play a vital role of reprocessing machine in our body. They are bean shape in structure and are located below the low rib cage and one on each side of the spine. A person`s kidneys process around 200 quarts of blood and purify them with the help of waste products and extra water in the form of urine.

The researchers at the University of Queensland have proclaimed on 13^th December, 2013 that they have created a kidney with the help of stem cells.

This research could cater some of the demands for transplant organs and improvisation for medical testing of new drugs for kidney related diseases.

Bentham Science Publishers is one of the remarkable publishers in the STM industry. One of their high impact factor journals is “Current Stem Cell Research & Therapy”  having articles on the current development.

Gene Therapy Cure

Medicine researchers are working tirelessly to find out new ways to eradicate illnesses. One of the most current researches is the cure via gene therapy. Gene therapy is the procedure in which a gene is inserted into the patient’s cell and tissues, which replaces the deleterious mutant allele with a functional one. Although there is always room for improvement, but the results of the therapy are promising.

Recently, researchers in Italy implanted mutated gene (which will eliminate the diseases gene) in children having diseases like Metachromatic Leukodystrophy and Wiskott-Aldrich Syndrome. In  metachromatic leukodystrophy, the babies appear healthy, but their development starts to reverse early in their childhood because parts of their brain is destroyed. While in Wiskott-Aldrich Syndrome, it leads to a faulty immune system.

Bone marrow stem cells of the patient are taken and are infused with the ‘virus’ carrying the snippets of DNA with the correct information and instructions. The researchers chose three children and injected the ‘virus’, before their disease started to appear. The result was very optimistic. The children were in better condition and wanted to carry on with their normal lives. The patients had to monitor more keenly, as compared to normal treatment patients but the outcome was very positive. The success of the gene therapy, assures that other diseases can be treated in the same manner.

Bentham Science Publishers is a major STM journal publisher of 116 online and print journals, 150 plus open access journals, and related print/online book series, Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences. Leading journals include Current Gene Therapy (Impact Factor 5.318), which is indexed in Science Citation Index Expanded™, Journal Citation Reports/Science Edition, and Index to Scientific Reviews®, Current Contents® /Life Sciences, Biotechnology Citation Index^® and many more.

Libraries Are Us!

Libraries are starting to become the trend of the past. The future holds the key to studies which are becoming electronic. The generation of the 21^st Century is moving forward towards electronic sources for learning. The new generation does not pay attention to the printed manuscript; they are more dependent on the eResources that are available at their fingertips. A person who has visited, studied and spent hours in a library for the preparation of exams understands the importance of a printed resource.

Library is a great means to diminish the difference between people. Individuals of all age groups, educational level, physical ability, income level can sit together and read to their heart’s content. A library not only equalizes but empowers the individual also. The huge array of books can hone one’s skills, instruct, support them to lead better lives. Libraries also build up the nation’s cultural heritage. They collect, preserve and reserve the history and culture of a nation in the books, and other documents. The importance of a library can always be confirmed by a scholar. Even a researcher, of the most initial level can also declare that the libraries are of utmost importance. Libraries are the robust columns which support the literacy of a nation. Many children and adults learn to read at their school and public libraries via story times, research projects, summer reading, tutoring and other opportunities. Others come to the library to learn the technology and information skills that help them answer their questions, discover new interests, and share their ideas with others.

The new era of electronic learning enhances the learning, but libraries open up the minds of the readers. Learning is a continuous quest, which can only be satiated by the huge assortment of books that a library offers. Libraries can be called out-dated by the new generation but they will never lose their importance.

Gene Therapy for the Treatment of Cancer

Hematological malignancy- a term specified to a set of cancers that hit and affects the bone marrow, lymph nodes and blood. Generally, the patients who suffer from Lymphomas, Myelomas and Leukemia are not able to discover a permanent treatment for their illness and do not survive the condition.

However, the latest advancements prove that gene therapy can be an exceptional development for the cure of various types of blood cancers. Researchers are positive about the usage of gene therapy in which the blood cells can actually be used to attack the cancerous cells. The testing’s, up till now have given promising outcomes and the patients does not show any signs and symptoms of cancer, after this medical treatment. This is genuinely accurate even for the myeloma, chronic lymphocytic leukemia and lymphocytic leukemia patients who were taking regular chemotherapies for years:

“Cancer was so advanced in 8-year-old Emily Whitehead of Philipsburg, Pa., that doctors said her major organs would fail within days. She was the first child given the gene therapy and shows no sign of cancer today, nearly two years later.”

In this treatment, the doctors are actually sorting out the white blood cells from the blood in massive quantities. These cells are then introduced in a lab to a particular gene targeting cancer, and then are induced back in the patient’s blood over a period of three days. This way, cancer is treated successfully and in a more productive method than chemotherapies, bone marrow transplants or stem cell.

Current Gene Therapy is a conventional, bi-monthly peer-reviewed journal from the shelves of Bentham Science Publishers. It has an impact factor rating, (5.318) and is indexed in major abstracting agencies, that includes; Scopus, EMBASE, MEDLINE/Index Medicus, and Journal Citation Reports etc. Current Gene Therapy publishes major topics concerning basic and clinical applications of gene and cell therapy. http://benthamscience.com/cgt/

The post is based on the article ‘Gene Therapy Scores Big Wins against Blood Cancers” by Marilynn Marchione.

Vitamins and Its Side Effects

Vitamins are very important for a healthy person. They are present in green, leafy vegetable, meat, and poultry, the list is very long. The diet of a normal person of the present times does not include all these healthy products. Deficiency of vitamins can lead to diseases like Scurvy, Beriberi and Rickets. People tend to replace the vitamins of the natural products with vitamin supplements. Although vitamins supplements play a vital role in keeping a healthy body, however over-dosage can cause more damage to our bodies. For majority of the people, taking vitamin supplements is known to be the best way to get vitamins for their bodies, instead of eating healthy food.

Balanced diet and sufficient levels of essential nutrients are important for complex processes in the body. Vitamins as supplement are introduced into our bodies at levels that could not be a replacement of healthier eating habits.

There are quality supplements available in the market. People usually take vitamin supplements Balanced diet and sufficient levels of essential nutrients are important for complex processes in the body. Vitamins as supplement are introduced into our bodies at levels that could not be a replacement of healthier eating habits.

The doctors all around the world prescribe vitamin supplements but their first suggestion always refers to the natural intake of vitamins that is meat, vegetables and other natural ingredients.

Bentham Science Publishers is one of the leading STM publishers in the world. It has a wealth of online journals and eBooks, which answers questions in the fields of pharmaceutical, biomedical, medical, and engineering, technology, computer and social sciences. One of its subscription based journal is “Current Nutrition and Food Sciences” having various related articles on this topic.

Heart Attack and Mental Disorders, Are they interrelated?

In the past, heart attack has been affiliated with depression, anxiety, stress and eating habits. A normal person was accused of having either of the above described. In the present times, medicine and research has excelled beyond the imagination of the Son of Adam.

Coronary Heart Disease is caused by residue or plaque built-up in the arteries, which lead to the heart. One in every four deaths, in the world, occurs due to heart diseases.

Research has now proven that those people who have mental disorders have a higher risk of developing Coronary Heart Disease (CHD). The people with any kind of psychological disorder also get affected by this disease. Now the factors of getting a heart attack have increased three-folds, because there are numerous mental disorders present in the world today. Mental maladies like Schizophrenia, Bipolar, depression, personality disorders and many more, increase the percentage of having a heart attack.

Bentham Science Publishers is one of the leading STM publishers in the world. It publishes 116 online and print journals, 150 plus open access journals, and related print/online book series, Bentham Science answers the information needs of scientists in the fields of pharmaceutical, biomedical, medical, engineering, technology, computer and social sciences. One of the subscription based journals is “Cardiovascular & Hematological Agents in Medicinal Chemistry”, each issue contains a series of timely in-depth reviews, original research articles and drug clinical trial studies written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry.

Different Brain Wiring in Men and Women:

Men and women are different in more than one ways. Not only do they look different, they also think differently. A new study suggests that their brains are in fact, wired in a different manner since birth.

Human brain has four parts, each having a different task. The back of the brain handles cognitive skills, while the front lobe handles action; the right side focuses on intuitive thinking, while the left hemisphere does all the logical thinking. The research suggests that male brain has a more active frontal lobe, suggesting an inclination towards motor or mechanical skills, while women’s brains react strongly to emotions and analytical processes.

A research was carried out involving scans of brains of around 1000 adults which concluded that male brains showed more connectivity within the hemispheres, whereas female brains were more connected between the hemispheres. In other words, women’s brains have shown to have a high degree of gray matter, which is the computational tissue of the brain, while men have a greater percentage of white matter, the connective cables of the brain.

Men and women are wired differently when it comes to reacting to pain as well. This study also suggests that women are more competent to deal with pain, as compared to men that explains why women can bear the severe pain of childbirth.  They need double dosage of painkiller than men, mainly because the part of the brain which reacts to pain is under developed in women and reacts slowly to painkillers. On the other hand, men’s brain is highly receptive, so reacts faster to anti-pain medicine.  Similarly, this suggests why women are more empathetic during stressful times, while men’s brain reacts with hostility.

The findings of the research could also assist researchers to understand why some of the diseases, like autism, are more recurrent in males.

Bentham Science Publishers is a recognized name in the STM industry, having journals and eBooks on various genres including; natural science, information technology, medicine etc. Bentham Science Publishers has an impact factor journal named “Neuroscience and Biomedical Engineering” which can help researchers for further investigation on the subject.

Please click on the following link to access it: http://benthamscience.com/nbe/index.htm

Allergic Thinitis

A group of symptoms of fever occurring in the eyes and nose is commonly called the Hay Fever, which is quite common during the haying season, hence the term. Hay Fever, which also goes by the name of Allergic Thinitis, is caused by dust particles, dander, and even pollens of certain plants.

Symptoms of hay fever include nasal congestion or obstruction, swelling in the eyelids and the middle ear effusion. In order to diagnose the problem, skin testing is the most reliable method. For treatment, there are various methods available, such as Nasal Corticosteroids, Antihistamines, and Decongestants etc. Immunotherapy and the rinsing of nasal passages with sterile saline are additional treatments for the hay fever.

In the field of inflammation and allergy drug discovery, “Recent Patents on Inflammation & Allergy Drug Discovery” is a useful research literature which publishes research and review articles in the field. Bentham Science Publishers has a publishing experience of 25 years and processes more than 20,000 articles for publishing on a yearly basis. Please log on to www.benthamscience.com for further information on “Recent Patents on Inflammation & Allergy Drug Discovery” and more journals and Recent Patents. 

ROBOT ALERT!

A few years back, one could not have imagined that the robots will be sitting in offices and working with the humans. After the creation, and perfection of robots, they were only considered as cold-hearted machines which only performed commands which were programmed in them. They were mostly used in factories to perform tasks with precision, speed and force. Now a days, science has excelled beyond the imagination of our fore-fathers. Today, robots are being used in academic research labs and, for fun, taking part in robotic soccer leagues. The first robots were confined in the industries, but now they have started to move and explore the world. Most of them are controlled by humans but the new latest designs are independent of human control. The scientists are working more and more towards making the robots look like humans. They, not only look like humans, but also can work along with humans. This new breed of ‘humanoid’ robots are being manufactured, designed and programmed in various companies. The studies on Robotics are now expanding and new things are being added, almost every day.

Bentham Science Publishers is a major STM journal publisher of 116 online and print journals, 150 plus open access journals. It also has eBooks on various subjects including Networking Humans, Robots and Environments. This book dives into the heart of how to design distributed control architectures for heterogeneous teams of humans, robots, and automated systems, enabling them to achieve greater cooperation and autonomy through the use of network technologies.

What is Medicinal Chemistry?

The field of medicinal chemistry can be used by humans to understand the molecular foundation of life. The discipline of Medicinal Chemistry explicates the relation of functions of molecules and structure. The combination of medicine and the chemical research methods are also included in the field of Medicinal Chemistry.

The Medicinal Chemistry has developed in recent years and will progress constantly pertaining to drug discoveries and its growth. In the past years, the scientists use to focus on separating the medicinal agents that are found in plants. However, in present days, the scientists are developing artificial drug compounds.

The long process of drug discovery and development includes mental, physical work and financial resources. The transfusion of a capable new compound into a drug and its launching in to the market which is a complex process has a costly expenditure that has reached $800million.

Bentham Science Publishers is a well established name in the industry of STM Publishing. They offer a wide range of journals on all recent topics of Medicinal Chemistry. This journal has an impact factor of 4.07. To read more about the medicinal chemistry drug development, please visit: http://www.benthamscience.com/cmc/.

The latest advances regarding medicinal chemistry are discussed in this journal from where the medicinal chemists can take information. It intends to contribute in the growth of scientific insights and facilitates the development and discovery of curative agents to treat human illnesses.

HIV AIDS- An Important Health Concern

HIV AIDS (Acquired Immunodeficiency Syndrome) - a persistent disorder, in which the white blood cells that are responsible for the prevention of diseases are attacked, therefore, it makes the human immune system weaker.  The (CD4+) T cells and the white blood cells, plays a vital role in fighting infections within the human body. When the virus hits the body and destroys these strong cells, the patient happens to be defenseless to severe infections and ailments.

HIV AIDS affects millions around the world and even more are at a threat of exposure to the virus. Each Year, on the 1^st December, World AIDS day is celebrated for enlightening the public on HIV AIDS so that more lives could be saved.

There is no such treatment that can cure the patients from HIV AIDS till date but health practitioners are working hard to discover treatments for HIV AIDS. There is a common treatment, usually called as ART (Antiretroviral therapy) is found to be the best treatment for HIV affected patients. However, ART cannot deracinate the infection completely but still it is an accepted practice of doctors that helps lengthen the patient’s life and make improvements to his health.

Over the past years, scholars have comprehensively studied AIDS; their findings are published in various scientific and medical journals. A Popular publication Journal ‘Current HIV Research’ covers the latest advances in the clinical fields of HIV. The journal includes virus replication, viral pathogenesis, HIV assembly, drug discovery, virus-cell interaction, anti-retroviral therapy and etc. the Journal publishes various research articles and reviews on the present perceptive of the virus and its multifaceted interaction with the host.

To learn more, please click: http://benthamscience.com/chivr/index.htm